MINI-REVIEW Antimicrobials, drug discovery, and genome ...

MINI-REVIEW Antimicrobials, drug discovery, ... REVIEW Antimicrobials, drug discovery, and genome mining R ... mining process. Many current antibiotics are ...

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NRPquest: Coupling mass spectrometry and genome mining for ...

NRPquest: Coupling mass spectrometry and genome mining for nonribosomal peptide ... Coupling mass spectrometry and genome mining for nonribosomal peptide discovery:

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Wilfred A. van der Donk, PhD Research Abstract | HHMI

Home › Research › Genome Mining for New Antibiotics. ... they are very well suited for genome mining and synthetic ... This process provides intramolecular ...

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Automated genome mining for natural products | BMC ...

Automated genome mining for ... and characteristics of key enzymes involved in assembly and tailoring ... domains that enable limited genome mining ...

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The Streptomyces leeuwenhoekii genome: de ... - BMC Genomics

... and genome mining of actinomycetes and other microorganisms is ... and enzymology involved in their ... subsystems technology. BMC Genomics ...

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Antibiotics from predatory bacteria - Beilstein-Institut

Antibiotics from predatory bacteria ... antibiotics; genome mining; Herpetosiphon; myxobacteria; predation ... which are involved

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Genome Sequences of Three Tunicamycin-Producing ...

... together with the published Streptomyces clavuligerus genome, will facilitate data mining of ... type antibiotics that ... unique steps involved in ...

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Mining the Genome: Big Science as Big Business -- A ...

MINING THE GENOME: BIG SCIENCE AS BIG ... to wait for the project to be completed to begin pursuing drugs or diagnostic procedures. ... who are involved should be ...

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antiSMASH 2.0—a versatile platform for genome mining of ...

mining of secondary metabolite producers Kai Blin1, ... Genome mining of their biosynthetic gene clusters has ... mates this process. Here, ...

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2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids ...

2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production ... GBLs are often involved in the regulation of ... Genome mining has become a ...

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Soil bacteria explored as source of new antibiotics

Soil bacteria explored as source of new antibiotics; Soil bacteria explored as source of new antibiotics. Effective antibiotics are a precious commodity.

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10.1139/gen-2013-0098 - NRC Research Press

To identify the gene clusters involved ... Characterization and analysis of an industrial strain of Streptomyces bingchenggensis by genome ... Genome mining in ...

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Genome mining reveals unlocked bioactive ... - BMC Genomics

We combined the genome mining with phenotypic evaluation of molecules potentially involved in production or ... In genome mining, ... BMC Genomics. 2008;9:75. View ...

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Genome mining of the biosynthetic gene cluster of the ...

Genome mining of the biosynthetic gene cluster of the polyene macrolide antibiotic tetramycin and characterization of a P450 monooxygenase involved ... antibiotic ...

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Antimicrobials, Drug Discovery, and Genome Mining - Dug Dug

... and genome mining’ in the journal ... the drug discovery process for antibiotics is becoming ... research going on and ask those involved what ...

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Strategies for the Design and Discovery of Novel ...

Strategies for the Design and Discovery of Novel Antibiotics using Genetic Engineering and Genome Mining. ... Genes and enzymes involved in bacterial ... steps during ...

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Genome mining of Streptomyces ambofaciens

Genome mining of Streptomyces ambofaciens ... potentially involved in the production of other secondary ... genome, the genome of ...

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Genome Mining of the Biosynthetic Gene Cluster of the ...

Genome Mining of the Biosynthetic Gene Cluster of the Polyene Macrolide Antibiotic Tetramycin and ... Involved in the ... by genome mining and ...

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GENE MINING - Scribd

Gene Mining - Free download as ... - Gene mining is the process of ... strategies of drug discovery Mining the mouse genome Global gene mining and the pharmaceutical ...

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Genome plasticity and systems evolution in Streptomyces ...

Genome plasticity and systems evolution in Streptomyces. Zhan Zhou 1, 2, ... biological process involved, ... which may play a role in the antibiotic efflux process.

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Bacteria - Wikipedia, the free encyclopedia

Bacteria were also involved in ... Those antibiotics kill bacteria ... Regardless of the type of metabolic process they employ, the majority of bacteria are ...

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Genome Mining of the Biosynthetic Gene Cluster of the ...

Genome Mining of the Biosynthetic Gene Cluster of the Polyene Macrolide Antibiotic Tetramycin and Characterization of a P450 Monooxygenase Involved in the ...

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Identification of thiotetronic acid antibiotic ...

Identification of thiotetronic acid antibiotic ... Identification of thiotetronic acid antibiotic biosynthetic ... in a process we call target-directed genome mining.

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New 'Genome Mining' Technique Streamlines Discovery from ...

New 'Genome Mining' Technique Streamlines Discovery from Nature New 'Genome Mining' Technique Streamlines Discovery from Nature. ... or "mining," information from ...

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Antimicrobials, drug discovery, and genome mining

Antimicrobials, drug discovery, and genome mining ... stopped searching for antibiotics. With the advent of genome ... Genome mining of their biosynthetic ...

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Molecular and Genetic Medicine - OMICS International

most effective way to achieve this is by regulating the process of ... exploited for antibiotic production [17,18]. Genome mining ... locus involved in global ...

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The Journal of Antibiotics - Genome mining and ...

Genome mining and biosynthesis of fumitremorgin-type alkaloids in ... type alkaloids by genome mining. ... involved in the reaction steps from L ...

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Streptomyces : Molecular Biology and Biotechnology | Book

... genomic mining and biotechnological ... of the biochemical steps involved in the production ... of a Streptomyces genome is being ...

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Genome Mining in Streptomyces. Elucidation of the Role of ...

Genome Mining in Streptomyces ... from two known producers of the sesquiterpenoid antibiotic ... enzymes involved in the early stages of ...

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Antimicrobials, drug discovery, and genome mining

Antimicrobials, drug discovery, and genome ... involved in the formation of new antibiotics, are useful in the genome mining process. Many current antibiotics are ...

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Genome Mining Reveals a Minimum Gene Set for the ...

Genome Mining Reveals a Minimum Gene ... we assumed that LazC and/or LazD might be involved in the ... which could direct thiopeptide family antibiotics to a new ...

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The Journal of Antibiotics - Genome mining of the sordarin ...

Journal of Antibiotics, ... Genome mining of ... to understand the unprecedented biosynthetic reaction mechanisms involved in the biosynthesis of 1, a genome ...

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Identification of Thiotetronic Acid Antibiotic ...

Identification of Thiotetronic Acid Antibiotic ... of Thiotetronic Acid Antibiotic Biosynthetic ... in a process we call target directed genome mining.

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Mining the Genome - MIT Technology Review

Biomedicine Mining the Genome. The Human Genome Project piles up Everests of data. But getting new drugs out of it will require sophisticated software for sniffing ...

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Glycogenomics as a mass spectrometry-guided genome-mining ...

Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. ... antibiotics; biosynthetic gene ...

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